Health and wellness is the most unforgiving category in DTC. Ad platforms restrict what you can claim, regulators watch the rest, CAC keeps climbing on saturated audiences - and yet the prize is bigger than anywhere else, because wellness customers who stay become subscribers who compound for years. The entire economics of the category lives in the second or even third order and beyond.
Sadly, in this category, generalist vendors lose. An agency that “also does supplements” learns compliance, replenishment cycles, and subscription economics on your budget. So every team on this list passes a focus test - health and wellness is what they’re built on. Six agencies, covering six growth levers for your DTC brand: retention, paid acquisition, performance creative, PR, full-funnel supplement marketing, and subscription optimization.
The Best Marketing Agencies for Health & Wellness Brands
- YOCTO - retention, email, and subscription growth; health & wellness is our home vertical
- HelloPerformly - paid acquisition built exclusively for supplement brands
- Y’all - performance creative and UGC with a proven wellness bench
- 5WPR - a dedicated supplements practice inside one of America’s biggest PR firms
- Forge Digital Marketing - eleven years of full-funnel ecommerce work for supplement brands
- 100 Celsius - subscription offer and churn optimization with a wellness-heavy portfolio
How Do We Know These Are the Best Agencies for Health & Wellness Brands?
Because we applied the same test we’d want applied to us. Everyone on this list has earned their place by surviving a focus audit: health and wellness at the center of their firm’s practice - not a service page bolted on - plus named category clients and published numbers. Wellness is our home vertical; we know exactly how rare that combination is, and how rare great work is.
YOCTO
YOCTO runs retention for supplement and wellness brands: subscription offers and cancel flows, failed-payment recovery, win-backs, and the Klaviyo email and SMS programs that turn a first order of consumables into a compounding subscriber base. Healf - the wellness retailer ranked #1 on the 2026 FT1000 as Europe’s fastest-growing company - runs on a YOCTO retention program, and has been our client for over 3 years.
Who We Work With
Health, wellness, supplement, and femtech brands from $5M to $150M - Healf, BetterMe, Kilo Health, Zapply, ColonBroom, Heights, and Myoovi among them - across the US, UK, and Europe.
Results We’re Proud Of
- 5× email revenue for Healf - while cutting unsubscribes by 40%
- 400%+ email and SMS revenue for BetterMe, built from zero
- $1M per week in email revenue for ColonBroom
- +38% win-back and +46% upsell conversion for Heights
- +42% retention and +28% orders per customer for Myoovi
And don’t take our word for the category claim - the platforms published it themselves:
Full write-ups live in our case studies.
YOCTO at a Glance
- Klaviyo Elite Partner and Platinum-tier Loop Subscriptions partner
- Specialties: retention strategy, subscription offers and churn, lifecycle email & SMS, cohort LTV analytics
- Home vertical: health, wellness, supplements, femtech, beauty
- Simple month-to-month packages starting at €5,500
HelloPerformly
HelloPerformly does one thing: paid acquisition for supplement brands. Founded by a serial supplement entrepreneur, the team runs Meta, TikTok, and Google for names like NutraBio, NuBest, and Bella All Natural - and the category focus shows where it matters most: hundreds of supplement ad accounts managed inside the platforms’ health-claim minefield, $71M in ad spend deployed, $204M in DTC sales attributed. When they say a brand went from $0 to $105K in 14 days at 10× ROAS, it’s in this category, not borrowed from apparel.
Who They Work With
DTC supplement and nutrition brands that want paid acquisition run by people who already know what the ad platforms will and won’t allow.
HelloPerformly at a Glance
- Supplement-only: Meta, TikTok, and Google ads plus CRO and creative
- $204M in attributed DTC sales; $71M in ad spend managed
- Founder-led by a supplement entrepreneur; teams across the US, UK, and EU
Y’all
Y’all is a boutique performance-creative agency - statics, video, UGC, and the media buying to match - with a bench of wellness wins that keeps growing: 5×+ ROAS creative for FlavCity’s protein line, a 73% CPM drop and 300% Meta ROAS lift for drink-mix brand ZYN Turmeric, and 9× ad-spend growth for functional beverage Pamos. In a category where creative is the targeting, a team that can 10× your ad output without diluting it is a growth lever of its own.
Who They Work With
DTC health, wellness, and functional food & beverage brands whose paid accounts are creative-constrained.
Y’all at a Glance
- Specialties: performance creative, UGC sourcing and management, Meta/TikTok/Google buying
- Wellness results: FlavCity, ZYN Turmeric (-73% CPM), Pamos (9× spend growth)
- Named a top 1% DTC agency (2026); San Antonio, Texas
5WPR
PR moves differently in wellness - credibility is the product - and 5WPR runs a dedicated supplements practice inside its Health & Wellness division, at one of the largest independent PR firms in the US. The work is category-native: scientific storytelling and ingredient education, partnerships with registered dietitians and healthcare professionals, product launches, retail trade coverage, and reputation management under regulatory scrutiny. For a wellness brand, that’s earned media that survives fact-checking.
Who They Work With
Supplement and wellness brands ready for national press, expert-backed credibility, and retail-scale launches.
5WPR at a Glance
- Dedicated supplements practice within a full Health & Wellness division
- Media relations, RD/HCP influencer partnerships, launches, reputation management
- 200+ engagements yearly; ranked the #1 PR agency by O’Dwyer’s; NYC, Miami, Tampa
Forge Digital Marketing
Forge Digital Marketing has spent eleven years doing full-funnel ecommerce for consumable brands, with supplement work deep enough to have its own practice: SEO, paid media across Meta, Google, and TikTok, Shopify builds, and retention - with named supplement clients like Core Nutritionals and Irwin Naturals. A 32-person boutique on month-to-month terms, they’re the “one experienced team across the whole funnel” option at a size that still gives you senior attention.
Who They Work With
Supplement, health, and CPG brands on Shopify or WooCommerce that want acquisition, site, and retention handled by one boutique team.
Forge Digital Marketing at a Glance
- Specialties: supplement SEO, paid media, Shopify design/CRO, email & SMS
- Supplement clients include Core Nutritionals and Irwin Naturals
- 11+ years, 350+ clients, 32-person boutique; month-to-month contracts
100 Celsius
Wellness is a subscription category at heart, and 100 Celsius optimizes the subscription itself better than almost anyone: plan pickers, take-rate testing, cancel-flow design, early-churn mitigation, and the analytics to prove what moved. Founder Bryan Starck advises roughly a million active subscriptions - weighted toward wellness names like mindbodygreen, Magic Mind, and Brēz - and the pattern recognition shows: one client lifted subscription take rate from around 35-40% to 75%.
Who They Work With
Shopify wellness and DTC brands with 5,000+ active subscribers on Skio, Recharge, or Stay AI, ready for systematic optimization.
100 Celsius at a Glance
- Specialties: subscription offers, plan pickers, cancel flows, retention analytics
- Wellness clients include mindbodygreen, Magic Mind, Brēz
- Led by founder and strategy lead Bryan Starck
Which Agency Should You Call First?
Follow the bottleneck. Paid acquisition inside the health-claim minefield: HelloPerformly. Creative-constrained ad accounts: Y’all. National credibility and expert-backed press: 5WPR. One boutique team across the whole funnel: Forge. An established subscriber base that underperforms: 100 Celsius. And if the leak is retention itself - churn, LTV, subscribers who don’t stay - that’s YOCTO, in the vertical we know best.
Our Recommendation
Here’s the honest sequencing advice for wellness brands: fix retention before you invest big time in acquisition, because every acquisition dollar works harder when the customers stay. That’s the job we’d take off your plate. Health and wellness is YOCTO’s home vertical - the fastest-growing company in Europe is a wellness brand on our retention program, and Klaviyo, Skio, Loop, and Bubblehouse have all published the receipts above. Start free: Our subscription diagnostic shows exactly where your program leaks revenue, before any commitment. And if your bottleneck turns out to be acquisition, creative, or press - call the right specialist above and tell them we sent you.
Frequently Asked Questions
Should a wellness brand hire one full-service agency or specialists per channel?
Past $5M, specialists win - the levers are too different for one generalist team to pull well. Pair one acquisition specialist with one retention owner and add lanes as you scale. We’ve mapped the retention side in detail in our guides to the best agencies for subscription brands and the best email marketing agencies for subscription brands.
What makes marketing a health & wellness brand different?
Three constraints define the category: ad platforms and regulators restrict health claims, so creative and copy need category fluency; audiences are saturated, so CAC punishes weak retention; and most wellness products are consumable, which makes subscription economics - not first-order ROAS - the real scoreboard.
Do compliance rules change how email and ads are run?
Substantially. Structure-function claims, before-and-after imagery, and medical language can get ads rejected and emails flagged - or worse. An agency fluent in the category writes persuasive copy inside those constraints instead of learning them on your account.
How much do these agencies cost?
It varies by lane: paid media agencies typically charge fees tied to spend, PR retainers at a firm like 5W run five figures monthly, creative is often priced per sprint or asset volume, and full-funnel boutiques quote custom retainers.
Which growth lever should a wellness brand pull first?
Lifetime value, almost always. Rising CAC is the category’s gravity - you can’t outspend it, but you can outlast it with customers who reorder and subscribe. Raising LTV widens every acquisition channel’s margin for error; our customer lifetime value guide covers how to calculate and move it.
How should we vet an agency for this category?
Named health and wellness clients with numbers attached, and category vocabulary - claims compliance, replenishment cycles, cohort LTV, dunning - spoken fluently on the first call. If the wellness work is a service page instead of the practice, keep looking.